Earlier this year, researchers found that many wild deer in Michigan had antibodies that suggested the animals had been exposed to SARS-CoV-2, the virus that causes COVID-19. It was a significant cause for concern, as a large population of susceptible animals could act as a reservoir that allows the virus to spread back to humans.
At the time, however, uncertainties abounded. The study looked at only a small sample of the deer population of one state—we didn't know how the animals were exposed, and we didn't know whether the virus was actually spreading among wild deer. Since then, a few of the blanks have been filled in. Critically, deer-to-deer transmission has been observed in captivity. On Monday, a preprint of a new paper answered some more questions, showing that infection is widespread in a second state, driven both by its spread from humans and deer-to-deer transmission.
Overall, the news is not especially good, though we still don't understand what risks it may pose to humans.
Virus hunting
There are still many unknowns about the spread of SARS-CoV-2 to deer and its transmission among them. We know that transmission to deer is possible, but we don't have a strong sense of how often the virus makes the jump from humans to deer or whether it does so directly or via an intermediary species. Once infected, deer show few obvious symptoms, but the virus has a similar time course: detectable after four days and remaining detectable as long as three weeks after infection.
The team included members of Iowa's Department of Natural Resources who were inspired by the findings in Michigan to see what was going on in their state. They partnered with a variety of academic researchers to test both wild deer and deer on game reserves, with many of the animals killed by hunters or cars. Their study began in April of 2020, but most of the 283 samples came after the hunting season started in September; things wrapped up in early January 2021.
To an extent, sampling paralleled the initial course of the pandemic in Iowa, which saw its first spike in cases in April of 2020 before reaching a peak at the end of the year. All told, 94 of the deer (33 percent) tested positive over the course of the study. But that figure obscures some obvious changes over time.
In deer, at least, the virus wasn't detected at all until after hunting season began, although the sampling rate in this period was too low to determine how significant this finding was. But the first positive deer were detected shortly after hunting season started, and the numbers rose considerably as cases in the human population spiked. By December, over 80 percent of the deer tested were positive for the virus.
How did that get here?
Sampling rates during the months of hunting season remained relatively steady, so that surge in cases appears to be real. But it's not possible to tell how much of the contribution came from hunters being out among the deer and how much came from the presence of a large number of humans who were infected with the virus. Hunting could also change the behavior of the deer in a way that made it easier for them to spread it among themselves.
To help figure out what might be going on, the research team obtained genomic sequences from the virus in all of their samples, allowing them to track individual lineages of virus and compare the viruses in deer to those from the surrounding human population.
The research team found a dozen different SARS-CoV-2 lineages in the deer population. The most common of these was also the most common among the strains circulating in humans in Iowa at the same time. Beyond that, there were some parallels between the deer and human strains, but the authors caution that the results represent a small sample of both populations, since genome sequencing of humans wasn't common at the time, either.
In any case, it's clear that deer from the same location were almost always infected by the same variant, and in some cases, the genomes of the viruses were identical. This finding provides strong evidence that the virus spreads among deer in the wild. The fact that different locations saw different variants present suggests that the cases were the product of separate inter-species infection events. Thus, it seems that the virus can regularly spread from humans to deer.
Does that spread happen directly? It's not possible to say, but the relatively short lag between the spike in human cases and the high levels of positivity in deer would seem to make an intermediate carrier species less likely.
While the virus doesn't cause much in the way of obvious symptoms for deer, they become infectious by four days after infection, and the virus remains detectable for up to three weeks after infection.
What does this mean?
The big reason not to hit the panic button is that we've yet to determine whether the virus can move from deer back to humans. The hunters would seem to be at the greatest risk, but there's no indication in this paper that their health was tracked following their involvement in the sampling.
That said, deer could provide a substantial reservoir for the virus. The species studied here, the white-tailed deer, has a population estimated at 25 million in North America, and many of those ungulates are found in areas with high human population densities. The two populations also regularly interact thanks to both hunting and traffic accidents.
A large reservoir like that poses a number of risks if there's a chance of a return spread to humans. Deer are obviously exempted from any of the public health measures we've used to limit the spread of the virus, so COVID is likely to spread unchecked among deer, which could provide a route for the virus to re-enter human populations where infections are rare.
In addition, the virus could evolve to thrive in its new hosts—with consequences for humans that are difficult to predict. The virus could become more specialized for deer, reducing the risk it poses to humans. Or the virus could evolve in ways that heighten either its spread or the symptoms it causes in human hosts. Finally, either of these changes could alter its immune profile in a way that limits the protection provided by vaccines or prior infection.
All of this means that we need to learn more about the risk of this form of interspecies infection as soon as we can.
Health - Latest - Google News
November 03, 2021 at 04:39AM
https://ift.tt/3mHeWEZ
New study suggests SARS-CoV-2 spreading widely within wild deer population - Ars Technica
Health - Latest - Google News
https://ift.tt/2zrj9Ud
Bagikan Berita Ini
0 Response to "New study suggests SARS-CoV-2 spreading widely within wild deer population - Ars Technica"
Post a Comment