Search

Defining the risk of SARS-CoV-2 variants on immune protection - Nature.com

musognaol.blogspot.com

Abstract

The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced following infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases (NIAID) within the National Institutes of Health (NIH) established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) program. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants potentially impacting transmission, virulence, and resistance to convalescent and vaccine-induced immunity. The SAVE program serves as a critical data-generating component of the United States Government SARS-CoV-2 Interagency Group to assess implications of SARS-CoV-2 variants on diagnostics, vaccines, and therapeutics and for communicating public health risk. Here we describe the coordinated approach used to identify and curate data about emerging variants, their impact on immunity, and effects on vaccine protection using animal models. We report the development of reagents, methodologies, models, and pivotal findings facilitated by this collaborative approach and identify future challenges. This program serves as a template for the response against rapidly evolving pandemic pathogens by monitoring viral evolution in the human population to identify variants that could erode the effectiveness of countermeasures.

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Florian Krammer, Tomer Hertz, Derek J. Smith, Michael S. Diamond, Diane J. Post or Mehul S. Suthar.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

DeGrace, M.M., Ghedin, E., Frieman, M.B. et al. Defining the risk of SARS-CoV-2 variants on immune protection. Nature (2022). https://ift.tt/GoSMkuF

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://ift.tt/GoSMkuF

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Adblock test (Why?)



Health - Latest - Google News
March 31, 2022 at 04:26PM
https://ift.tt/4CY3oIz

Defining the risk of SARS-CoV-2 variants on immune protection - Nature.com
Health - Latest - Google News
https://ift.tt/cK59kn3


Bagikan Berita Ini

0 Response to "Defining the risk of SARS-CoV-2 variants on immune protection - Nature.com"

Post a Comment

Powered by Blogger.