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Yet more data support COVID-19 aerosol transmission - CIDRAP

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Two studies published late last week in Clinical Infectious Diseases highlight the role of airborne spread of COVID-19 and the importance of efficient ventilation systems. One study found that patients can exhale millions of viral RNA particles per hour in the early stages of disease, and the second tied an outbreak affecting 81% of residents and 50% of healthcare workers at a Dutch nursing home to inadequate ventilation.

In the first study, researchers in China analyzed exhaled breath samples from 49 COVID-19 patients from 10 countries, 4 hospitalized patients without COVID-19, and 15 healthy people from Beijing using reverse transcription polymerase chain reaction. They also tested 26 air samples and 242 surface swabs from quarantine hotels, hospitals, and personal belongings.

Of the exhaled breath samples, 26.9% were positive for RNA from SARS-CoV-2, the virus that causes COVID-19, while 3.8% of air samples and 5.4% of surface swabs tested positive. The viral RNA breath emission rate was highest in the first stages of disease.

Breath samples from two patients were positive for coronavirus RNA, but surface swabs of their cell phones, hands, and toilets were negative. Viral RNA was also detected on an air ventilation duct below another patient's bed.

Semi-enclosed environments

Among the 242 surface swabs, viral RNA was found most often on toilet bowls (16.7%); floors (12.5%); patient hands, pillowcases, mobile phones, and computer keyboards (4.0%); and surfaces that healthcare staff touched (2.6%). But only 2 of 22 mobile phone surface samples tested positive for viral RNA, and all object handles were negative.

The authors said that the viral RNA breath emission rate appears to vary based on factors such as patient activity level and disease stage and may be affected by age. Viral RNA emission was sporadic in at least one patient, whose samples generated different test results on different days.

The findings support previous studies that concluded that COVID-19 is mostly likely spread by aerosols rather than large respiratory droplets or contaminated surfaces, the researchers said. Such studies have documented airborne spread in semi-enclosed environments such as a choir practice in Washington state and a restaurant in Guangzhou, China.

"Though we did not study infectivity or transmission probability and other virus releasing activities such as talking and singing, our study demonstrates that exhaled breath emission plays an important role in SARS-CoV-2 emission into the air, which could have contributed greatly to the observed airborne cluster infections and the ongoing pandemic," the authors wrote.

Stale indoor air

In the second study, researchers in Rotterdam and Utrecht, the Netherlands, wrote a research letter documenting a COVID-19 outbreak that sickened 17 residents and 17 healthcare staff in one of seven wards in a nursing home for people with psychiatric or behavioral conditions. None of the 95 residents or 106 healthcare staff in the other six wards tested positive.

The authors noted that the Netherlands was experiencing a low prevalence of COVID-19 the week of the outbreak, with only 493 of that country's residents testing positive, compared with 8,391 cases during the most intense week of the outbreak in April.

To prevent coronavirus transmission, all healthcare workers were assigned to specific wards and required to wear surgical masks during patient care starting Apr 26. Residents lived in individual rooms and spent part of each day in shared living rooms; some residents were mobile.

Suspecting that the ventilation system of the affected ward could have contributed to the outbreak, investigators found that an energy-efficient system had been installed in which indoor air was refreshed only when indoor carbon dioxide (CO2) concentrations detected elevated levels. If CO2 levels didn't exceed a certain threshold, unfiltered indoor air was simply recirculated throughout the ward. In contrast, the six unaffected wards were refreshed regularly with outside air.

The researchers noted that low CO2 levels produced by inactive patients may have led to stale air in the affected ward, which was cooled by two air conditioning units that also recirculated the air in the shared living areas. SARS-CoV-2 RNA was found in dust on the mesh dust filter of living room air conditioners and in four filters from three of eight ventilation units.

The research letter was written in support of findings of a study published in the same journal on Jul 6 warning of the hazards of airborne COVID-19 transmission in poorly ventilated environments.

"We advise that prevention of COVID-19 transmission should take into account the possibility of aerosol transmission in healthcare facilities and other buildings where ventilation systems recirculate unfiltered inside air," the authors of the Aug 28 study wrote.

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Yet more data support COVID-19 aerosol transmission - CIDRAP
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